The objective of our work is to make a pharmacological study of molecules derived from 4-phenyl-1,5-benzodiazepin-2-one\ncarrying long chains so that they have a structure similar to surfactants, with the benzodiazepine as a hydrophilic head and\na carbon chain as a hydrophobic tail. First, we studied the acute toxicity of the above mentioned 4-phenyl-1,5-benzodiazepin-2-one\nderivatives. This study was conducted according to OECD 423 guidelines in female mice and revealed that these compounds are\nnontoxic. We then assessed the psychotropic effects of our products on the central nervous system (CNS). The results obtained\nshow that 4-phenyl-1,5-benzodiazepin-2-one has no sedative effect at therapeutic doses of 100 and 200 mg/kg. On the other hand,\nits long-chain derivatives possess them. Moreover, all these products have no cataleptic and hypnotic effects at the doses studied.\nBut at 100 mg/kg, these compounds all have the ability to significantly prolong the hypnotic effect of thiopental sodium.
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